The AFL Commission announced on Tuesday that interchange rotations would be capped at 120 per match over the next two seasons.
Leuenberger said it could force first-choice ruckmen to rest deep in the forward line, rather than heading to the interchange bench for a breather.
"It doesn't seem that much when you're talking (reducing interchange from an average of) 135 to 120, but I think you'll find it will be quite a significant change," he said.
The 204cm, 102kg Lions ruckman is having a stellar season and fought out a gripping four-quarter duel with Western Bulldog Will Minson on Sunday.
Both essentially played as one-out ruckmen and although Leuenberger said his running ability was one of his strengths, a change in strategy could be required from next season.
"It might become more important to have a genuine back-up ruckman, perhaps, so you can go forward and have a genuine one come in," he said.
The Lions' only other genuine ruck option is 20-year-old Billy Longer, who is yet to be re-signed after nine games in two seasons at the club.
Leuenberger said it was crucial the Lions persisted with Longer.
"The hardest teams to play against from my perspective are the ones that have two genuine ruckmen," he said.
"You never get a chop-out against a key forward where you can build your game if you're struggling.
"He's got a ton of talent and ruckmen take time. I definitely think he's got a lot to offer and it's just a matter of being patient with him."
Twitter: @AFL_mikewhiting
